Reduced FDG dose levels for PET/MRI show mixed results
Even though a lower dose of
FDG had no significantly adverse effect on lesion detection for most adult
cancer patients undergoing a whole-body PET/MRI scan, German researchers
recommend that clinicians stay with recommended levels to avoid artifacts,
according to a study published online March 30 in the Journal of Nuclear Medicine.
The researchers found that FDG
dose could go as low as 2 MBq/kg based on body weight (BW) with no significant
degradation in diagnostic image quality in most middle body areas. However, FDG
doses below the standard level of 3 MBq/kgBW also resulted in large artifacts
in the abdominal/pelvic region (JNM, March 30, 2017).
"The occurrence of this
artifact cannot currently be predicted and the clinical impact is
unclear," wrote lead author Dr. Ferdinand Seith from Eberhard Karls
University Tubingen and colleagues. "Therefore, we do not recommend
reducing doses below 3 MBq/kgBW in oncologic PET/MRI examinations in adults at
this time."
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Source: AuntMinne.com