Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, presented preclinical data that provides further support of its FPI-1966 and FPI-2059 targeted alpha therapies (TATs) at the 34th Annual European Association of Nuclear Medicine Congress.
Data
from preclinical studies of FPI-1966, a TAT designed to target and deliver
actinium-225 to cancer cells expressing FGFR3, were presented in an oral
presentation titled, "FGFR3 Targeted Alpha Therapeutic [225Ac]-FPI-1966
induces regression in preclinical bladder xenograft model". Outcomes
demonstrated that FPI-1966 when administered with vofatamab, results in high tumor delivery and low off-target
uptake. Furthermore, the data
showed therapeutic efficacy of FPI-1966 at both single and multiple doses
in a preclinical bladder cancer xenograft model.
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