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F-18 flortaucipir PET and postmortem assessment of Alzheimer disease neuropathologic changes

Visual reads of [18F]flortaucipir positron emission tomography (PET) scans may accurately support a pathological diagnosis of Alzheimer’s disease (AD) according to a recent article published on JAMA Neurology. In this diagnostic study of 82 individuals with or without dementia, visual reads of F-18 flortaucipir PET scans corresponded with postmortem Braak stages V and VI levels of cortical neurofibrillary tangles and high levels of AD neuropathological change. Therefore, PET may increase the diagnostic accuracy and confirm the underlying neuropathologic changes of AD.


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Source: JAMA